The 2018 International Symposium on Biofabrication in Space, organized by the Laboratory for Biotechnological Research of 3D BIOPRINTING SOLUTIONS, Russian State Space Corporation ROSCOSMOS and SKOLKOVO FOUNDATION will be held in Skolkovo, Russia on 11 April, 2018.
The aim of the symposium is to discuss the current state and prospects for the development of new biofabrication technologies and the possibility of their use in space.
A fundamentally new approach to bioprinting called "formative production” is possible to enable in microgravity conditions. The bioprinters developed for carrying out such experiments will allow creating various organ constructs, including those sensitive to radiation, for assessing the adverse effect of cosmic radiation on the health of astronauts in the missions to the Moon and Mars.
The symposium will be attended by leading foreign and Russian experts in the field of experiments in space and biofabrication:
Dr. Demirci is currently a Professor at Stanford University School of Medicine with tenure at the Canary Center for Early Cancer Detection. Prior to his Stanford appointment, he was an Associate Professor of Medicine at Brigham and Women's Hospital, Harvard Medical School and at Harvard-MIT Division of Health Sciences and Technology serving at the Division of Biomedical Engineering, Division of Infectious Diseases and Renal Division. He leads a group of 20+ researchers focusing on micro- and nano-scale technologies. He received his B.S. degree in Electrical Engineering in 1999 as a James B. Angell Scholar (summa cum laude) from University of Michigan, Ann Arbor. He received his M.S. degree in 2001 in Electrical Engineering, M.S. degree in Management Science and Engineering in 2005, and Ph.D. in Electrical Engineering in 2005, all from Stanford University. ology Review TR35 as one of the top 35 innovators in the world under the age of 35
Matteo Moretti is head of the Cell and Tissue Engineering Lab at IRCCS Galeazzi Orthopaedic Institute, Milan, Italy. Prior to this he worked as postdoctoral fellow at Massachusetts Institute of Technology, Harvard-MIT Div. of Health Science and Technology, Langer Lab. Both of his degrees, B.Eng (Politecnico di Milano) and research M.Sc (Trinity College Dublin, with Prof. P.J. Prendergast) are in Bioengineering. He obtained a European Ph.D from Politecnico di Milano, pursuing his research also in Prof. I. Martin’s Tissue Engineering Lab at U. Basel. His main research interests lie within osteochondral and cardiovascular tissues and bioreactor technologies. In particular, on engineered tissues and in vitro model systems, 3D tumor models, tissue vascularization and in multi-scale bioreactor systems as a key to more viable and accessible tissue and cell therapies. He is member of the TERMIS-EU Council and invited Expert Reviewer for various Governments and Institutions, amongst which EU-FP7/HORIZON2020, UK BBSRC, Hong Kong ITC, Portugal FCT, German BMBF, Netherlands ZonMw and ETH Zurich. He has been awarded a number scientific prizes including a N.A.S.A. Tech Brief Award for development of scientific or technical innovations. Industrially, he has been coordinator of EU Projects for Fidia Advanced Biopolymers, has a licensed patent and is co-founder of 2 biotech startups (SKE s.r.l. and CELLEC A.G.) focused on bioreactor technologies.
DANIELA G. GRIMM
Prof. Dr. Daniela Grimm: Gravitational Biology and Translational Regenerative Medicine
Otto-von-Guericke University Magdeburg
Professorat Space Medicine, Institute of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark
Specialist: Clinical Pharmacology and Internal Medicine
Prof. Dr. Daniela Grimm is working on the growth behaviour of spheroids from different cell types, for example thyroid carcinoma cells, chondrocytes and endothelial cells in weightlessness. Cells in weightlessness are not influenced by gravitational or centrifugal forces. Therefore, changes in the cells are to be attributed to genetically given cell structures. Under the conditions of weightlessness, these cells start to grow in form of spheroids.
The world-wide first time establishment of space-spheroids can be performed with the help of a so-called Random Positioning Machine (RPM, Dutch Space, NL). The investigation of spheroids might help to avoid animal testings in the field of pharmacology and medicine. They also can be used in cancer research. An important keyword is tissue engineering, which is possible with the help of a RPM (Grimm et al., 2009).
Furthermore, Prof. Dr. Daniela Grimm’s working group investigates endothelial cells with regard to mechanisms of apoptosis and changes in the extracellular matrix. Under the conditions of weightlessness, endothelial cells growing in form of tubular structures, which might be useful in the field of tissue engineering.
LYUDMILA B. BURAVKOVA
Acting Deputy Director for Research, Institute of Biomedical Problems, Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences. Lyudmila Buravkova is the author and co-author of more than 200 scientific articles, collective monographs on the mplementation of scientific programs on biosatellites, experimental studies involving human subjects in the modeling of space flight factors and factors of the hyperbaric habitat.
Currently Prof. Dr. Buravkova heads the department "Molecular Cell Biomedicine" and the laboratory "Cellular physiology". She is a recognized expert in the field of space biology, physiology of extreme states and gravitational cytophysiology.
Area of scientific interests:
• studying the cellular mechanisms of adaptation to hypoxia,
• Investigation of the role of intracellular signaling in adaptive reactions under the action of altered oxygen content and pressure of the gaseous medium,
• analysis of cellular effects under the action of space flight factors, the role of modification of the cytoskeleton and the expression of adhesion molecules when the cell adapts to altered gravity,
• Investigation of the plasticity of the progenitor cells and the intercellular interaction.
Prof. Dr. Buravkova is a full member of the International Academy of Astronautics (Paris), a member of the International Committee on High Pressure Biology, a member of the editorial board of the journals "Human Physiology", "Aerospace and Environmental Medicine" and "Cell Technologies in Biology and Medicine." In addition to scientific work, L. Buravkova is engaged in teaching activities, being a professor at the Department of Ecological and Extreme Medicine of the Faculty of Fundamental Medicine of the Lomonosov Moscow State University. Professor Buravkova heads the course of "Space Medicine" and lectures on barophysiology in the course of "Medical Ecology"