In my talk I am going to overview current trends in implementation of genome data in personalized medicine approaches in Japan. Several ambitious projects, including Tohoku Medical MegaBank providing data for Integrative Japanese Genome variation database are supported by government and the first results illustrate importance of in-deep geographically-oriented genome projects. Remarkably, Russia and Japan face similar issues, suffering from lack of “national” genomes knowledge in gene diagnostics. Limited data on nation-specific features of genomes reflect on daily medical assistance, for example in the field of onco-diagnostics. Since 2015, in the frame of collaboration among RIKEN, Tatarstan Cancer Center and several Russian institutions we have initiated pilot “Pharmaco-FANTOM” project.  Based on the next-generation sequencing data, we analyze the primary sequence of key genes with clinical diagnostics importance both in somatic and germline polymorphism. The first data have revealed several critical clinical cases where European and USA standards and targets in cancer diagnostics have only limited applicability in Russia.

 

Oleg Gusev

 

Oleg Gusev is a senior researcher and projects manager in newly established in 2013 RIKEN Preventive Medicine & Diagnosis Innovation Program, Japan. He has graduated from Kazan Federal University in 2001, and then, as a scholar of MEXT program moved to Japan where he obtained PhD in Molecular biology in 2007. After several year working at National Institute of Agrobiological Sciences as JSPS Postdoctoral Fellow, Oleg was invited to Japan Space Agency, where he curated joined Russia-Japan space experiments in life sciences. Since 2015 he serves as and principal investigator at RIKEN and as adjunct principal investigator at RIKEN-affiliated joint laboratory at Kazan Federal University. Field of the expertized of Oleg covers comparative genomics and RNA transcription analysis with various applications in adaptation biology and bio-medicine.